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    A monoclonal antibody called daratumumab that targets CD38 has become a transformational treatment for a variety of hematologic malignancies, most notably multiple myeloma (MM). The treatment of relapsed/refractory MM and newly diagnosed patients who are not eligible for transplant has been revolutionized by its exceptional efficacy, both when used alone and in conjunction with other therapies. Understanding major trends and future directions is crucial for all parties involved in hematology-oncology treatment as the daratumumab market continues to change due to improvements in clinical practice, research, and regulatory approvals.

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